Introduction: Insulin resistance (IR) is known as the most important cause of Liver Disorders, Which is associated with decreased expression of Peroxisome proliferator-Activated Receptor-alpha (PPAR-α) and increased expression of Sterol regulatory Element Binding Proteins (SREBP-1C) and Carbohydrate response element binding protein (CHREBP) in diabetic type 2 male rats. The aim of this study was to evaluate the effect of eight weeks of aerobic exercise on hepatic PPAR-α , SREBP-1C and CHREBP expression and IR in n diabetic type 2 rat. Materials and methods: In this experimental study, 27 male Wistar mice were randomly divided into three groups of healthy control, diabetic control and diabetic exercise. Medium and progressive aerobic exercise protocol on the treadmill was performed and The trainings lasted 8 weeks and 5 days/week. At the end of the trainings PPAR-α, SREBP-1C and CHREBP expressions were examined via ELISA technique in the liver tissue. One-way Analysis of variance (ANOVA) test were used to compare the groups and the significance level was considered at p < 0.05. Results: The post-hoc test results indicated a significant reduction in IR between the diabetic control group and aerobic training (P<0.05). Despite a notable increase in hepatic expression, it PPAR-α, SREBP-1C and CHREBP was statistically significant Conclusion: aerobic exercise for eight weeks improved IR in type 2 diabetic rats. There was a significant difference in the expression of liver proteins between the groups.

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