The unbridled growth of bio-hazardous waste generation is a global environmental challenge that has attracted researchers’ attention to the development of new generations of engineered biocompatible and biodegradable materials. Fully natural biocomposites made of wood fibers extracted from agricultural residues and bound together by sustainable growth of fungal network matrix are widely under investigation over the last few years as potential alternatives to synthetic foams. In this study, three cylindrical samples of a mycelium-based biocomposite with identical composition and dimensions but different pre-pressures were fabricated, and their mass-specific compressive properties were studied at different compression levels. This biocomposite material consists of a natural substrate of shredded leaf sheaths of date palm, as the reinforcement fibers, within a network of Pleurotus, a fungal mycelium species, as the binding matrix. Results showed that compressive strength varies with pre-loading and ranges from 0.34 to 4.55 MPa, which is comparable with synthetic packaging foams.

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