ABSTRACT Objective: The COVID-19 pandemic has been challenging for everyone since it is confronted with various precautions such as lockdowns. For those who stay healthy and protect themselves from COVID-19, physical exercise and activity might be an effective solution since it has specific impacts on the immune system. Methods: MEDLINE and SportDiscus data from the US National Library of Medicine were used to search for scientific literature related to this review. The terms \\\"coronavirus”, \\\"physical exercise”, and \\\"immune system\\\" were used. The relevant literature has also taken its source from the research of relevant articles from reference lists derived from data studies. An additional search for the term “dance and movement therapy” was made in Google Scholar generally because it is considered a proposal to promote well-being and high immunity in a community traumatized by the pandemic. Well-being and immune response were assessed in a separate search with the terms “well-being” and “immune”, several additional sources were used to link a multisystem perspective. Results: The effects of physical exercise and activity have been proven useful in defending the body against COVID-19 by supporting the immune system. Therefore, people should perform daily physical exercises and activities as advised during quarantine. They also should consider various factors such as intensity, duration, and amount of training, with appropriate rest time. Also, exercises such as movement and dance therapy including the type of movement that can engage physiological processes as a way to increase emotional regulation, and activities that potentially become more accessible in quarantine through conscious participation have been considered as a form of physical exercise. Conclusions: Studies show that physical exercise and activities significantly affect the immune system since they form an immune response to various infections, viruses, etc. In addition, some factors, such as the intensity and duration of exercise, are essential. Dance and movement therapy as a home-based physical training helps counterbalance the destructive physical and mental side effects of COVID-19. Dance and movement therapy exercises that bring people together are beneficial in terms of psychosocial primary care, mood, and physical and mental health.

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