Introduction: The Blood-Brain Barrier (BBB), made up of endothelial cells, in the cerebral micro-vessels control brain-body communication and prohibit harmful delivery to the brain. Carrier shape, elasticity, size, locomotion, and charge are essential features in BBB penetration. In this paper, we review several possible theoretical brain delivery venues using artificial intelligence and biomimicry. Literature review: The brain, as the central controller of the body organs, needs more protection in substance delivery. This issue creates opportunities and challenges for mimicking safe and possible brain delivery. Several theoretical brain delivery carriers are investigated, such as nanoparticles (NPs), polymeric NPs, lipid-based NPs, inorganic NPs, and biomimetic NPs. There are also several categories for various biomimetic NPs, including cell membrane biomimetic NPs, cell-loaded NPs, extracellular vesicles (EVs)-loaded NPs, and virus-like NPs. One of the main issues in brain delivery is NPs’ clearance from the reticuloendothelial system; therefore, immune cells such as macrophages, neutrophils (NEs), dendritic cells, and monocytes are proper delivery carrier candidates. Neural stem cells also improve the delivery process. In addition to biomimicry, artificial intelligence helps the brain delivery with ‘precise’ control, targeted delivery, prediction of BBB permeability, preparing safe and simple delivery by applying soft computing and machine learning algorithms. Result: Considering biomimicry basis for delivery, artificial intelligence can help to model, infer, design, and control efficient brain delivery carriers. Conclusion: Effective brain delivery is a gate to quicker brain disease improvement. There is a barrier to brain delivery as BBB in which proper delivery needs the help of multidisciplinary research, e.g., artificial intelligence, material, and medicine. This paper reviews several state-of-the-art brain delivery mechanisms, focusing on artificial intelligence and biomimicry.

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