Background: In recent years, immunotherapy for cancer therapy has made significant progress, particularly in stem cell immunotherapy. The goal of stem cell immunotherapy is to prevent the onset of cancer by using stem cells that self-renew and differentiate into different types of cells, including immune cells. To investigate the most recent clinical findings on the use of immunotherapy effects of stem cells in colon and breast cancer treatment, a systematic review of published articles was conducted. Methods: The study searched nine databases, including PubMed, Scopus, and Google Scholar, for relevant articles published between January 2000 and January 2023. From the search results, 20 articles with complete abstracts were included in the study, and data analysis was performed using R version 4.2.1 artificial intelligence software. Results: Based on the study results, stem cell immunotherapy demonstrated to be highly effective in cancer treatment research. By targeting drug delivery to cancer cells, stem cells can minimize toxicity to healthy cells while targeting drug delivery to cancer cells. Furthermore, stem cells release TRAIL, a pro-apoptotic cytokine that induces apoptosis in colon and breast cancer cells. The secretion of anti-tumor factors by stem cells, such as Interleukin 12 (IL-12) and IL-24, also inhibits tumor growth and angiogenesis. The use of bone marrow mesenchymal stem cells has also been shown to be highly effective in the treatment of colon and breast cancer. Additionally, adipocyte mesenchymal stem cells showed great promise for treating breast cancer. Conclusion: In conclusion, immunotherapy leveraging stem cells to target and destroy cancer cells has shown promise as a cancer treatment. Using stem cells to deliver targeted drugs to cancer cells while minimizing toxic effects on healthy cells is an effective way to target drug delivery to cancer cells.Keywords: Immunotherapy, Stem cells, Cancer treatment, Mesenchymal stem cells

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