Background: There is no doubt that cancer is one of the leading causes of death in the world today. As of right now, there is still no effective way of curing this disease, and it has remained a major challenge for the current chemotherapy treatments. An overview of the most recent research on phytosome complexes and cancer therapy has been presented in this study. This study summarizes the strategies for synthesizing these complexes and the mechanism by which they move through phytosomes. Methods: Eleven databases (Embase, Scopus, Google Scholar, PubMed, Cochrane Library, Magiran, UpToDate, SID, Medline, Elsevier, and Lilacs) were searched for published articles on the treatment of cancers with nano-herbals from January 2002 to January 2023. Seventeen affiliated articles with complete abstracts were included in this study. All data were extracted from interrelated papers and analyzed with R version 4.2.1 artificial intelligence software. Results: Silibinin is a natural component extracted from silymarin and has been observed to have anti-cancer activities by decreasing N-nitrosodiethylamine in hepatocellular carcinomas. Sinigrin has healing effects on normal human keratinocytes cells (HaCaT) and concurrently investigated its phytosomal formulation anti-cancer effects on A-375 melanoma cells. Mitomycin C (MMC), a natural compound containing a carbamoyl chain and an aziridine ring, has shown potent antitumor activities; thus, it is utilized in a variety of cancers. T. arjuna (TA), a member of the Combretaceae family, the bark is rich in flavonoids and has antimutagenic anti-cancer activities. Luteolin (Lut), a natural component, has been found to have anti-cancer activities by acting on multiple molecular targets to kill cancer cells due to its potency to inhibit selectively the Nrf2 signaling pathway and sensitize non-small lung cancer cell lines. Conclusion: Evidence suggests that phytosomal formulations of phytoconstituents may enhance their anticancer properties.

Keywords