Background: These days, effective and safe vaccination illustrates cost-effective and strong economic development and international health techniques. In veterinary medicine, vaccination is necessary to enhance public health and defeat zoonoses. Nevertheless, there is a need for new vaccination systems to manage persistent infective, rapidly growing, and emerging/re-emerging pathogens for which no helpful vaccine has been designed. Nanoscience in veterinary medicine particularly pays attention to three principal factors: diagnosis, vaccination, and treatment. This study will discuss Nano-Biotech programs related to vaccination science. Methods: Nine databases (PubMed, Scopus, Google Scholar, Cochrane Library, Magiran, SID, Medline, Embase, and Lilacs) were searched for published articles on Nano-Vaccinology in Veterinary Medicine Science from January 2000 to January 2023. Twenty-five affiliated articles with complete abstracts were included in this study. All data were extracted from interconnected papers and analyzed with R version 4.2.1 artificial intelligence software. Results: Nano vaccines are successful because of the enhanced lowest Immunotoxicity, antigen stability, better immunogenicity, the flexibility of the physical characteristics of nanomaterials, and sustained release. Nano vaccines are more efficient than ordinary vaccines due to ease of control and plasticity in physio-chemical properties. Based on Nano-Vaccination, both humoral immunity and cellular responses can be invoked. By engineered Nano-Vaccines, highly targeted immunological pathways may be achieved, which is required for long-lasting and solid immunity. Some of Nano-Vaccines\\\' positive features are controlled drug release, increased drug stability, and improved targeting capacity. Antigen-carrying Nano-Particles can influence the immune system and improve the T-cell cytotoxic response against antigens linked to Nano-Particle. Conclusion: This study article uses Nano-Vaccinology to avoid infectious diseases such as viral, bacterial, parasitic, and noninfectious ones, including auto-immunity and cancer. In addition, as a future research field, successful application challenges from bench to clinical usage have been highlighted.

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