Title : ( Association of a Genetic Variant in Chromosome 9p21 with Increased Risk of Developing Cervical Cancer )
Authors: Mojde Atabati , Razieh Saber , Parnian Malakuti , Ghazaleh Pourali , Motahareh Heydari-majd , Pegah Safavi , Mohammad Dashti , Azam Rastgar Moghadam , Farzad Rahmani , Marjaneh Farazestanian , Negin Behboodi , Mehrane Mehramiz , Mohammadreza Nassiri , Majid Rajabian , Raheleh Rahbarian , Hassan Ramshini , Amirhosein Jafarian , Gordon A Ferns , Amir Avan , Malihe Hasanzadeh ,
Full TextAbstract
Background: Cervical cancer is one of the most prevalent gynecologic cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in chromosome 9p21 and the risk of cervical carcinogenesis. Methods: The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method. Results: The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia using recessive and additive genetic models (p < 0.001). Conclusion: Our findings indicated that the CDKN2A/B genetic variant (rs1333049) was significantly associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical carcinogenesis.
Keywords
9p21; Cervical cancer; genetic variant; gynecologic cancers; human malignancies; rs1333049
@article{paperid:1096101,
author = {مژده عطاباطی and صابر and ملکوتی and پورعلی and حیدری and صفوی and دشتی and رستگار and رحمانی and فرازستیان and بهبودی and مهرامیز and Nassiri, Mohammadreza and رجبیان and رهبریان and رمشینی and جعفریان and گوردان and امیرآوان and حسن زاده},
title = {Association of a Genetic Variant in Chromosome 9p21 with Increased Risk
of Developing Cervical Cancer},
journal = {Current Cancer Therapy Reviews},
year = {2023},
volume = {19},
number = {4},
month = {November},
issn = {1573-3947},
pages = {358--362},
numpages = {4},
keywords = {9p21; Cervical cancer; genetic variant; gynecologic cancers; human malignancies; rs1333049},
}
%0 Journal Article
%T Association of a Genetic Variant in Chromosome 9p21 with Increased Risk
of Developing Cervical Cancer
%A مژده عطاباطی
%A صابر
%A ملکوتی
%A پورعلی
%A حیدری
%A صفوی
%A دشتی
%A رستگار
%A رحمانی
%A فرازستیان
%A بهبودی
%A مهرامیز
%A Nassiri, Mohammadreza
%A رجبیان
%A رهبریان
%A رمشینی
%A جعفریان
%A گوردان
%A امیرآوان
%A حسن زاده
%J Current Cancer Therapy Reviews
%@ 1573-3947
%D 2023
