The present study aims to provide insights into the effectiveness of curcumin nanocapsules in treating hydatid infections. Following five months after infection, 45 mice were divided into six groups. Groups 1, 2, and 3 were treated daily with curcumin nanocapsules (0.5, 0.25, 0.125 mg/ml) for one month. Group 4 was treated with curcumin (0.5 mg/ml), group 5 was treated with albendazole (150 mg/kg), and group 6 was the negative control group without treatments (only received saline). A detailed analysis of the cysts\\\' physical characteristics, including their size and weight, has been conducted, and the data obtained has been recorded in designated tables. The Zeta potential spectrum of the nanocapsules was in the range of 0 to -45 millivolts. Regarding the total cyst numbers, all three nanocapsule groups had significantly lower total cyst numbers than the curcumin, albendazole, and negative control groups. Regarding the total cyst weight, all three nanocapsule groups had a significantly lower total cyst weight than the curcumin and negative control groups. Regarding the cyst with the maximum size, nanocapsules groups 1 and 2 had a significantly smaller size than the curcumin, albendazole, and negative control groups. In conclusion, curcumin nanocapsules can serve as suitable alternatives to chemical drugs.

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