Title : ( Effects of Dietary Cerium Oxide Nanoparticles on Growth Performance, Plasma Biochemistry, and Histopathological Changes of Cyprinus Carpio Koi Fish Exposed to Florfenicol Antibiotic )
Authors: Fatemeh BorjianBoroujeni , Davar Shahsavani , Mehrdad Sarkheil , Hossein Nourani ,
Full TextAbstract
This studywasconductedtoinvestigatetheeffectsofdietaryceriumoxidenanoparticles(CeO2-NPs), ongrowthperformance, plasma biochemistryandhistopathologicalchangesofkoi fish (Cyprinus carpio koi) exposedto florfenicol (FF)antibioticina 60-day experiment.The fish withanaverageweightof2.380.44 gwerecompletelyrandomlydistributedintosixdifferentgroups with threereplications.Theexperimentalgroupsincluded:Basaldietwithoutadditives(control),basaldiet +oral antibiotic,basal diet +antibiotic bath,basaldietsupplementedwithCeO2-NPs, basaldietsupplemntedwithCeO2-NPs+antibiotic bath,andbasal diet supplementedwithCeO2-NPs+oral antibiotic.Theexperimentalunitwasaglassaquariumwithacapacityof110Lofwater and 10 fish werestockedinit.Attheendoftheexperimentalperiod,growthperformanceof fish, bloodplasmaindices,and histopathology ofliver,kidney,gill,andintestinewereinvestigated.Theresultsshowedthatthe final bodylengthofthe fish inthe basal diet +antibiotic bathgroupwassignificantly higherthanthecontrolgroupandthebasaldietsupplementedwithCeO2-NP+ oral antibioticgroup(p <0:05). Histologicalstudiesshowedthatthekidney,liver,andintestinallesionsof fish indifferentgroups did notdiffermicroscopically.Ingilltissues,changesinsecondarylamellaeandtheirdestructionoccurredindifferentpartsofthe primary lamellaeindifferentgroups,butoverall,nodifferenceswereobservedamongthedifferentgroups.Theplasmaaspartate transaminase (AST)andalaninetransaminase(ALT)levelsweresignificantly decreasedinallgroupscomparedtothecontrol (p <0:05), exceptthebasaldietsupplementedwithCeO2-NPs+antibiotic bathgroup.Theplasmabloodureanitrogen(BUN) level decreasedsignificantly inthebasaldietsupplementedwithCeO2-NPs+antibiotic bathgroupcomparedtothecontrol,while this valueincreasedinthebasaldiet+oral antibioticandthebasaldietsupplementedwithCeO2-NPs+oral antibioticgroups compared tothecontrol(p <0:05). TheresultsofthisstudyrevealedthataddingCeO2-NPs tothebasaldietatlevelof0.8mg/kg decreased thealkalinephosphatase(ALP),AST,andALPlevelsinplasmaofkoi fish comparedtothecontrol(p <0:05). The simultaneous administrationofdietaryCeO2-NPs withthebathandoralFFantibioticincreasedtheASTandALTlevelsandthe BUN levelinplasma,respectively(p <0:05).
Keywords
antibiotic; ceriumoxidenanoparticles; florfenicol; koi fish; toxicity
@article{paperid:1103837,
author = {فاطمه برجیان بروجنی and Shahsavani, Davar and Sarkheil, Mehrdad and Nourani, Hossein},
title = {Effects of Dietary Cerium Oxide Nanoparticles on Growth Performance, Plasma Biochemistry, and Histopathological Changes of Cyprinus Carpio Koi Fish Exposed to Florfenicol Antibiotic},
journal = {Aquaculture Research},
year = {2025},
volume = {2025},
number = {1},
month = {July},
issn = {1355-557X},
keywords = {antibiotic; ceriumoxidenanoparticles; florfenicol; koi fish; toxicity},
}
%0 Journal Article
%T Effects of Dietary Cerium Oxide Nanoparticles on Growth Performance, Plasma Biochemistry, and Histopathological Changes of Cyprinus Carpio Koi Fish Exposed to Florfenicol Antibiotic
%A فاطمه برجیان بروجنی
%A Shahsavani, Davar
%A Sarkheil, Mehrdad
%A Nourani, Hossein
%J Aquaculture Research
%@ 1355-557X
%D 2025
