Background: Parasitic infections in animals are not only associated with immune and physiological consequences, but also induce significant changes in autonomic neural responses. The neurophysiological axis of these responses, which is mainly mediated by the sympathetic and parasympathetic nervous systems, plays an important role in maintaining homeostasis under chronic stress conditions caused by infection. In this article, the physiological modeling of these responses was investigated with emphasis on factors such as heart rate changes , pupil dilation, feeding behaviors, and restlessness or immobility in animals infected with parasites. Methods: In this study, a number of articles related to the relationship between parasitic infections in animals and disruption of the autonomic nervous system were reviewed, and interesting findings were found regarding this effect. Results: Since the aim of this text was to analyze the neural mechanisms involved in regulating autonomic responses to the presence of parasites and to evaluate the role of neurotransmitters and neural pathways in facilitating or inhibiting these responses, a review of studies has shown that parasites such as Trypanosoma cruzi, Toxoplasma gondii, and Plasmodium species can cause changes such as tachycardia, anorexia, and disruption of physiological rhythms by activating the HPA axis and stimulating certain areas in the brainstem and cortical and subcortical areas of the brain. Conclusion: Finally, these autonomous responses, although initiated with the aim of maintaining host survival, may in some circumstances act in the parasite\\\'s favor, including by suppressing immunity or altering host behavior to enhance transmission. A detailed understanding of these pathways could open new horizons in the treatment of parasitic diseases and clinical management of parasitic diseases. keywords: Autonomic nervous response, Parasitic infections, Physiological modeling, Anorexia, Feeding behaviors.

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