Journal of Asian Natural Products Research, ( ISI ), Volume (12), No (7), Year (2010-7) , Pages (569-575)

Title : ( The enhancement of vincristine cytotoxicity by combination with feselol )

Authors: Samaneh Mollazadeh , Maryam Moghaddam Matin , Mehrdad Iranshahi , Ahmad Reza Bahrami , Vajiheh Neshati , Fatemeh Behnam Rassouli ,

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Urinary bladder cancer is one of the most common cancers worldwide. Human transitional cell carcinoma (TCC) cells are epithelial-like adherent cells originally established from a primary bladder carcinoma. Studies have shown that TCC cells are resistant to some chemotherapeutic agents such as vincristine (VCR). In the present study, the effect of feselol, a sesquiterpene coumarin isolated from the fruits of Ferula badrakema, was investigated on VCR effectiveness. Our results demonstrated that feselol itself did not have any cytotoxic effect on TCC cells. In order to check its combinatorial effects, TCC cells were exposed to various combined concentrations of feselol and VCR. Then, morphological changes were monitored and cytotoxicity was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay for three consequent days. Results showed that the combination of 40mg/ml VCR with 16mg/ml feselol increased the cytotoxicity of VCR by 28.32% after 48 h. This effect might be due to inhibition of P-glycoprotein in TCC cells by feselol.

Keywords

Ferula badrakema; sesquiterpene coumarin; feselol; vincristine; TCC
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@article{paperid:1016622,
author = {Mollazadeh, Samaneh and Moghaddam Matin, Maryam and Mehrdad Iranshahi and Bahrami, Ahmad Reza and Neshati, Vajiheh and Behnam Rassouli, Fatemeh},
title = {The enhancement of vincristine cytotoxicity by combination with feselol},
journal = {Journal of Asian Natural Products Research},
year = {2010},
volume = {12},
number = {7},
month = {July},
issn = {1028-6020},
pages = {569--575},
numpages = {6},
keywords = {Ferula badrakema; sesquiterpene coumarin; feselol; vincristine; TCC cells},
}

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%0 Journal Article
%T The enhancement of vincristine cytotoxicity by combination with feselol
%A Mollazadeh, Samaneh
%A Moghaddam Matin, Maryam
%A Mehrdad Iranshahi
%A Bahrami, Ahmad Reza
%A Neshati, Vajiheh
%A Behnam Rassouli, Fatemeh
%J Journal of Asian Natural Products Research
%@ 1028-6020
%D 2010

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