Background: Interleukin-6 is excreting by adiposities, which increased by overweight and obesity. Overweight and obesity causes a large number of health problems.Obesity-related inflammatory marker is a promising predictor for diseases. However, the effect of exercise training, and other therapy that can reduce weight, on IL- 6 is still unclear. We examined the effects of two weight loss protocol on resting plasma concentration of IL-6 in the overweight and obese health sedentary female of college students. Methods: A total of 30 subjects (age = 21.9±2.4, weight=75.6±5.57, Height=161±4.79, BF% =29.53± 3.18, BMI = 29.04±2.22 kg/m2) randomly divided into three experimental and one control groups. Experimental groupI: Experienced twelve-day of researchers proposed diet (D), experimental groupII: either Experienced twelve-day and researchers proposed diet along with twelve-day running training (intensity was 60 to 70 %HRmax for 50 minutes) every other day mid consumption 250Cc water beverage during per aerobic exercise period (AEDW), experimental groupIII: Experienced twelve-day and researchers proposed diet along with twelve-day running training (intensity was 60 to 70 %HRmax for 50 minutes) every other day mid consumption 250Cc 12% glucose soluble during per aerobic exercise period (AEDG) and control group (C) remained sedentary with normal diet in this period. Results: After doing the programs, weight in experimental groups was reduced (P<0.0001). Resting plasma concentration of IL-6 was significantly decreased, for both AEDW (p<0.001) and AEDG (p<0.01) groups. Conclusions: AEDW and AEDG, lowered IL-6 plasma concentration at rest. AED is an optimal pace for decreasing of rest plasma IL-6. Furthermore, according to finding of present study, AEDW is better than AEDG for weight loss.

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