Zeitschrift fur Naturforschung C: Biosciences, ( ISI ), Volume (66), No (66), Year (2011-12) , Pages (555-561)

Title : ( Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells )

Authors: Samaneh Mollazadeh , Maryam Moghaddam Matin , Ahmad Reza Bahrami , Mehrdad Iranshahi , Morteza Behnam Rassouli , Fatemeh Behnam Rassouli , Vajiheh Neshati ,

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Transitional cell carcinoma (TCC), which is the most common type of bladder cancer, shows resistance to chemotherapeutic agents due to the overexpression of drug effl ux pumps. In this study, the effects of feselol, a sesquiterpene coumarin extracted from Ferula badrakema, on cisplatin cytotoxicity were investigated in 5637 cells, a TCC subline. Cell viability and DNA lesion were evaluated by thiazolyl blue tetrazolium bromide and comet assays, respectively. Feselol had no signifi cant cytotoxic effect in 5637 cells but at 32 μg/mL it increased the cytotoxicity of 1 μg/mL cisplatin by 37% after 24 h. Furthermore, the comet assay revealed that DNA damage induced by cisplatin in 5637 cells is enhanced by 31% when used in combination with feselol. Therefore, feselol might be considered as an effective reversal agent for future in vivo and clinical studies.

Keywords

, Feselol, Cisplatin, 5637
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@article{paperid:1025211,
author = {Mollazadeh, Samaneh and Moghaddam Matin, Maryam and Bahrami, Ahmad Reza and Mehrdad Iranshahi and Behnam Rassouli, Morteza and Behnam Rassouli, Fatemeh and Neshati, Vajiheh},
title = {Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells},
journal = {Zeitschrift fur Naturforschung C: Biosciences},
year = {2011},
volume = {66},
number = {66},
month = {December},
issn = {0939-5075},
pages = {555--561},
numpages = {6},
keywords = {Feselol; Cisplatin; 5637 Cells},
}

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%0 Journal Article
%T Feselol Enhances the Cytotoxicity and DNA Damage Induced by Cisplatin in 5637 Cells
%A Mollazadeh, Samaneh
%A Moghaddam Matin, Maryam
%A Bahrami, Ahmad Reza
%A Mehrdad Iranshahi
%A Behnam Rassouli, Morteza
%A Behnam Rassouli, Fatemeh
%A Neshati, Vajiheh
%J Zeitschrift fur Naturforschung C: Biosciences
%@ 0939-5075
%D 2011

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