Iranian Journal of Veterinary Science and Technology, ( ISI ), Volume (3), No (1), Year (2011-12) , Pages (21-28)

Title : ( Macroscopic evaluation of wound healing activity of the Persian shallot, Allium hirtifolium in rat )

Authors: Hamideh Ghodrati Azadi , Behrooz Fathi Hafshejani , Hossein Kazemi Mehrjerdi , MOHSEN MALEKI , hany shaterzadeh , ,

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Wound is a break in the outer layer of skin. There are different methods for treatment of wounds, such as topically or orally administration of medicinal drugs or herbal remedies. Persian shallot, Allium hirtifolium belongs to the same genus of garlic and naturally growing in different parts of Iran. In this study, the wound healing activity of hydro-alcoholic extract of A .hirtifolium Boiss, on full-skin-thickness wounds evaluated. Four adult albino rats weighing 165±35 g were selected. Under general anesthesia, four full-thickness wounds were made on the dorsal area of each animal, right side wounds treated as experimental groups and left side wounds treated as control groups. One day after creation of wounds, the gel form solution of mixed extract of A. hirtifolium and methylcellulose were applied to the experimental wounds at 100 mg/kg topically while the wounds in control groups treated with the extract-free solution. Wounds were daily treated for 12 days. At days 1, 3, 6, 9 and 12, digital photos of wounds provided and by using of Scion image software, the percentage of contraction, epithelialisation and speed of healing were measured. The results showed that A. hirtifolium can accelerate wound healing by increasing the rate of epithelialisation. We conclude that A. hirtifolium extract may be clinically useful in management of open wounds treatment.

Keywords

, Allium hirtifolium, epithelialisation, extract, wound
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@article{paperid:1025560,
author = {Ghodrati Azadi, Hamideh and Fathi Hafshejani, Behrooz and Kazemi Mehrjerdi, Hossein and MALEKI, MOHSEN and Shaterzadeh, Hany and , },
title = {Macroscopic evaluation of wound healing activity of the Persian shallot, Allium hirtifolium in rat},
journal = {Iranian Journal of Veterinary Science and Technology},
year = {2011},
volume = {3},
number = {1},
month = {December},
issn = {2008-465X},
pages = {21--28},
numpages = {7},
keywords = {Allium hirtifolium; epithelialisation; extract; wound healing},
}

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%0 Journal Article
%T Macroscopic evaluation of wound healing activity of the Persian shallot, Allium hirtifolium in rat
%A Ghodrati Azadi, Hamideh
%A Fathi Hafshejani, Behrooz
%A Kazemi Mehrjerdi, Hossein
%A MALEKI, MOHSEN
%A Shaterzadeh, Hany
%A ,
%J Iranian Journal of Veterinary Science and Technology
%@ 2008-465X
%D 2011

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