Family Muridae consists of eight genera and 28 species in Iran. This family shows notable variability of karyological features. In this study, karyological data derived from 11 species of 7 genera of this family of Iran are presented and compared with previously published accounts. The included species were: Mus musculus musculus from Gonbad (2n=40, FN=40) and Birjand (2n=40, FN=38), Rattus norvegicus (2n=42), Apodemus uralensis (2n=48), Apodemus avicennicus (2n=48), Apodemus hyrcanicus (2n=48), Apodemus witherbyi (2n=48) from Zanjan and Gorgan, Nesokia indica (2n=42), Meriones libycus (2n=44), Meriones persicus (2n=44), Meriones crassus from Kashmar (2n=54) and Tabas (2n=60), Tatera indica from Zabul (2n=68) and Hoveyzeh (2n=66) and Rhombomys opimus (2n=40).

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