Abstract: Fibrinogen, CRP and resistin are three novel cardiovascular risk factors. The aim of this study was to examine the effects of an eight weeks aerobic exercise program on concentrations of these factors in healthy and overweight middle aged men. Thirty inactive middle aged men whom their BMI was between 25 and 30 randomly assigned into experimental and control groups (each group 15 subjects). Subjects of the experimental group accomplished eight weeks (three sessions per week) aerobic exercise with intensity of 50 to 70 percent of their maximum heart rate. Before and after trainings weight, body fat percent, fibrinogen, CRP and resistin levels of subjects were determined. Obtained data were analyzed using independent samples T test. After trainings results showed a significant reduction of weight, BMI, body fat percent, fibrinogen and CRP and significant elevation of resistin in the experimental group (P<0.05). Overall, eight weeks regular aerobic exercise through reduction of weight, body fat, fibrinogen and CRP and elevation of resistin cause reduction of risk of atherosclerosis and improvement of antioxidant system in overweight middle aged men.

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