20th Iranian Seminar of Organic Chemistry , 2013-07-03

Title : ( Synthesis of some novel 1,3,4-thiadiazine containing tetrazolonucleus )

Authors: Hossein Eshghi , Mohammad Rahimizadeh , Kh. Abnous , satar saberi ,

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1,3,4-Thiadiazines represent the most widely studied class of compounds among the six theoretically possible thiadiazine isomers; they are of interest in a chemical sense because they are labile compounds which are capable of undergoing intramolecular rearrangements to give thiazole and pyrazole derivatives. Moreover, 1,3,4-thiadiazinesexhibit a broad spectrum of biological activity 1 .In addition, tetrazole derivatives have been attracting attention due to their diverse pharmacological properties. For example, Angiotensin II receptor blockers such as losartan 2 and candesartan 3 , contain tetrazole ring.In this study we described the synthesis of six novel Tetrazolo[5,1-b][1,3,4]Thiadiazines(5a–f) and (6a-f) wherein the biologically active 1,3,4-thiadiazine moiety is fused to a potent tetrazol ring across the 2,3-positions (Scheme 1).

Keywords

, 1, 3, 4-Thiadiazines represent the most widely studied class of compounds among the six theoretically possible thiadiazine isomers; they are of interest in a chemical sense because they are labile compounds which are capable of undergoing intramolecular rearrangements to give thiazole and pyrazole
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@inproceedings{paperid:1035431,
author = {Eshghi, Hossein and Rahimizadeh, Mohammad and Kh. Abnous and Saberi, Satar},
title = {Synthesis of some novel 1,3,4-thiadiazine containing tetrazolonucleus},
booktitle = {20th Iranian Seminar of Organic Chemistry},
year = {2013},
location = {همدان, IRAN},
keywords = {1;3;4-Thiadiazines represent the most widely studied class of compounds among the six theoretically possible thiadiazine isomers; they are of interest in a chemical sense because they are labile compounds which are capable of undergoing intramolecular rearrangements to give thiazole and pyrazole derivatives. Moreover; 1;3;4-thiadiazinesexhibit a broad spectrum of biological activity 1 .In addition; tetrazole derivatives have been attracting attention due to their diverse pharmacological properties. For example; Angiotensin II receptor blockers such as losartan 2 and candesartan 3 ; contain tetrazole ring.In this study we described the synthesis of six novel Tetrazolo[5;1-b][1;3;4]Thiadiazines(5a–f) and (6a-f) wherein the biologically active 1;3;4-thiadiazine moiety is fused to a potent tetrazol ring across the 2;3-positions (Scheme 1).},
}

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%0 Conference Proceedings
%T Synthesis of some novel 1,3,4-thiadiazine containing tetrazolonucleus
%A Eshghi, Hossein
%A Rahimizadeh, Mohammad
%A Kh. Abnous
%A Saberi, Satar
%J 20th Iranian Seminar of Organic Chemistry
%D 2013

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