Objectives: The purpose of this study was to determine the effects of using caffeine and trans-Cinnamaldehyde (TC) on serum glucose, ALT/SGPT, AST/SGOT and cholesterol level in male broilers chicks under stress induced by dexamethasone. Materials and Methods: This experiment was conducted in a completely randomized design with 200 of broiler (Ross-308) in 4 treatments and 5 replicate (with 10 hens in each replicate) from 1 to 42 days and included: 1) control group without any additives, 2) 0.5% caffeine powder 3) 1% TC 4) 0.5% caffeine powder + 1% TC. At 42 day of the experiment, the blood vessels of the neck for glucose, ALT, AST and cholesterol level measurements of each replicate were slaughtered as a chicken's cervical dislocation method. Bloods serums were separated and send to the laboratory to do next. Serum glucose, ALT, AST and cholesterol were analyzed with Auto Analyzer (Bio Systems S. A. – Costa Brava 30, 08030 Barcelona, Spain). All data were analyzed by the analysis of variance option GLM of SAS/STAT software and when treatment means were significant (P < 0.05), Tukey’s multiple range tests was used to compare means. Results and Conclusion: The result showed that caffeine and TC had no significant effects on blood parameters in 42d. Based on the data from this experiment, it was concluded that caffeine, TC and mixture of caffeine + TC dose not affect on blood parameter in male broilers chicks under stress induced by dexamethasone.

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