Objective- Lidocaine hydrochloride is an antiinflammatory, analgesic and local anesthetic drug that today used broadly in balanced anesthesia. We decide to assess effect of this drug on oxidative stress parameters in dogs undergoing ovariohysterectomy. Design- Randomized, Double blind, Experimental study Animals- Ten female dogs were included. They were of mix breed, and the average of weight was 24.59 kilograms. Procedures- Ten healthy mix breed of female dogs, randomly divided into treatment (Lidocaine CRI) andcontrol (Placebo) groups.Anesthesia was done using atropine (0.03 mg/kg SC), morphine hydrochloride(0.1 mg/kg IM), and acepromazine (0.05 mg/kg IM) as premedication, and followed by midazolam (0.2 mg/kg IV) and ketamine (5 mg/kg IV) as an induction. Isoflurane in 100% oxygen was used for maintenance of anesthesia. Treatment group received lidocaine loading dose (2mg/kg IV)immediately after induction, and followed within 5 min by a CRI (100μg/kg BW per minutes) using a syringe pump. Control group received an equivalent volume of saline instead of lidocaine as a placebo. Blood samples were collected before premedication, before linea Alba suturing, after extubation, and 24 hours after surgery. MDA, Thiol, and FRAP were measured as an oxidative stress parameters. Results- For continuous quantitative variables repeated measure of ANOVA were used. There were no significant difference in Malondialdehyde (p=0.292), Thiol (p=0.217), and Frap (p=0.345)between treatment and control group; also no significant changes were seen in different times of sampling between each group (MDA; P=0.569, Thiol; P=0.834, Frap; P=0.134). Conclusion and Clinical Relevance- In different studies lidocaine dispensed IV decreased Isoflurane end-tidal concentration in a dose dependent manner in dogs, and cat. The study of Smith and coworkers in 2004 resulted in reduction of post-operativeocular pain after the systemic administration of lidocaine. Surgical trauma cause oxidative stress in animals undergoing surgery, and due to lidocaine anti-inflammatory and analgesic effects we expected infusion of lidocaine intravenously may decrease oxidative stress parameters, however, our resultsunlikely have shown different findings.

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