Introduction and Objectives: Urinary tract infection (UTI) is the second most common cause of infection in human. Escherichia coli is the most common (80%) cause of urinary tract infection. Increasing antibiotic resistance in Escherichia coli leads to treatment failure and recurrence. Due to different patterns of antibiotic resistance of E.Coli in each area, study of antibiotic resistance is necessary. The present study was designed to determine the antimicrobial susceptibility pattern of E.coli isolated from urine culture of patients admitted to several hospitals and laboratories in Mashhad. Materials and Methods: One hundred of Escherichia coli positive samples were isolated from urine samples of patients with urinary tract infection who had not received antibiotics and antibiotic susceptibility testing. Combined disk method was used to detect UTI E-coli. All data analyzed in SPSS version 19. Results: From 100 isolated E.coli, 71% and 29% of strains were isolated from women and men, respectively. The most antibiotic resistance rates were as follow: Ampicillin (78%), Cephalothin (68%) and Cotrimoxazole (65%). The least resistance rate Amikacin (1%), Nitrofurantoin (5%), Gentamycin (19%) and Norfloxacin (30%) were identified. Conclusions: In our study, the most effective antibiotic for UTI E-coli isolated from patients with a sensitivity of 99% , was Amikacin. In constract, the highest resistance was to ampicillin (78%). According to results of this study, antibiogram test using proper antibiotic disks, the rational prescription indiscriminate use of antibiotics and also avoiding of use of unprescribed antibiotics are necessary.

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