This study was conducted to determine the effects of 8-weeks administration of testosterone enanthate (TE) in conjunction with resistance training on thyroid hormones and lipid profiles. Sixty male adult Wistar rats were randomly divided into 6 groups; C: olive oil, RT: resistance training + olive oil, LD: TE (20 mg.kg-1); HD: TE (50 mg.kg-1); RT+LD: RT+TE (20mg.kg-1); RT+HD: RT+TE (50 mg.kg-1). The RT consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail. At the end, blood specimens were obtained from the orbital sinus and serum concentration of T4, T3, TSH and lipid profiles were determined. The serum concentration of TSH significantly increased in RT+HD group compared to C and the serum concentration of T4 significantly decreased in LD, HD, RT+LD and RT+HD groups compared to the C and RT groups (p<0.05). The concentration of HDL and cholesterol significantly decreased in HD and RT+HD groups compared with C group (p<0.05). Both decreased T4 and increased TSH in the RT+HD group likely suggested a primary hypothyroidism as a complication of high dose administration of testosterone enanthate along withresistance training. Alteration in lipid profile was another complication observed in rats received high doses of testosterone enanthate.

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