Journal of Investigative Surgery, Year (2018-3) , Pages (1-8)

Title : ( Allium Sativum Methanolic Extract (garlic) Improve Therapeutic Efficacy of Albendazole Against Hydatid Cyst: In Vivo Study )

Authors: Khadijeh Hajimohammadi , Mohammad Heidarpour , Hassan Borji ,

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Abstract

After gas chromatography and mass spectrometry of prepared methanolic extract of Allium sativum, 40 laboratory BALB/c mice were infected intraperitoneally by injection of 1,500 viable protoscoleces. Five months after infection, the infected mice were allocated into four treatment groups, including 1- Albendazole (100 mg/kg); 2- Allium sativum methanolic extract (10 mL/L); 3- A. sativum methanolic extract (10 mL/L) + Albendazole (50 mg /kg); and 4- untreated control group. After 30 days of daily treatment, total number and weight of cysts and size of the largest cyst as well as blood serum bilirubinand liver enzymes were compared between the mice of different groups. The total number and weight of cysts and size of the largest cyst were significantly lower in treated groups A. sativum 10 mL/L+Albendazole 50 and Albendazole 100 in comparison to those of the control group (p < 0.05). Theactivityofalanineaminotransferase(ALT)enzymeandbilirubinconcentrationweresignificantlylowerinthe mice treated with A. sativum 10 mL/Land A. sativum 10 mL/L+Albendazole 50, when compared to the control group. In addition, bilirubin concentration revealed significant decrease in A. sativum 10 mL/L and A. sativum 10 mL/L + Albendazole 50 groups, when compared to the Albendazole group. In conclusion, administration of A. sativum 10 mL/Limproved the anti-hydatidosis activity of Albendazole 50 mg /kg, due to parasitological effects similar to Albendazole 100 mg /kg but less hepatotoxic effects.

Keywords

, Allium sativum, Albendazole, biochemistry, hydatid cyst
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@article{paperid:1068328,
author = {Hajimohammadi, Khadijeh and Heidarpour, Mohammad and Borji, Hassan},
title = {Allium Sativum Methanolic Extract (garlic) Improve Therapeutic Efficacy of Albendazole Against Hydatid Cyst: In Vivo Study},
journal = {Journal of Investigative Surgery},
year = {2018},
month = {March},
issn = {0894-1939},
pages = {1--8},
numpages = {7},
keywords = {Allium sativum; Albendazole; biochemistry; hydatid cyst},
}

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%0 Journal Article
%T Allium Sativum Methanolic Extract (garlic) Improve Therapeutic Efficacy of Albendazole Against Hydatid Cyst: In Vivo Study
%A Hajimohammadi, Khadijeh
%A Heidarpour, Mohammad
%A Borji, Hassan
%J Journal of Investigative Surgery
%@ 0894-1939
%D 2018

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