Cardiovascular & Hematological Disorders-Drug Targets, Volume (20), No (2), Year (2019-9) , Pages (138-144)

Title : ( Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men )

Authors: Ehsan Asghari , Amir Rashidlamir , Seyyed Reza Attarzadeh Hosseini , Mahtab Moazzami , Saeed Samarghandian , Tahereh Farkhondeh ,

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Abstract

Abstract: Background: Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of resistance training (RT) in human. Objective: Current research was designed to show the effect of high-intensity resistance training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6, and TNF-α in the low activity men. Method: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8∼10 repetitions at 70∼75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-reactive protein (CRP), irisin, tumor necrotic factor (TNF-α) and interleukin-6 (IL-6). Results: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05). Conclusion: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

Keywords

, Ursolic acid, Irisin, C-reactive protein, IL-6, TNF-α, resistance training.
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@article{paperid:1076147,
author = {Asghari, Ehsan and Rashidlamir, Amir and Attarzadeh Hosseini, Seyyed Reza and Moazzami, Mahtab and سعید سمرقندیان and طاهره فرخنده},
title = {Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men},
journal = {Cardiovascular & Hematological Disorders-Drug Targets},
year = {2019},
volume = {20},
number = {2},
month = {September},
issn = {1871-529X},
pages = {138--144},
numpages = {6},
keywords = {Ursolic acid; Irisin; C-reactive protein; IL-6; TNF-α; resistance training.},
}

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%0 Journal Article
%T Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men
%A Asghari, Ehsan
%A Rashidlamir, Amir
%A Attarzadeh Hosseini, Seyyed Reza
%A Moazzami, Mahtab
%A سعید سمرقندیان
%A طاهره فرخنده
%J Cardiovascular & Hematological Disorders-Drug Targets
%@ 1871-529X
%D 2019

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