Background:The currently approved treatment for arsenic toxicity is chelationtherapy to reduce the burden of the toxic effects of arsenic, but the safetyand efficacy of the various chelating agents may be questioned.The aim of this work was to study the alleviative role of caffeicacid, a dietary non-flavonoid phenolic acid, versus arsenite-provokedalterations in testicular oxidative status indices. Methods: In this experimental study, 24 mice were divided into four groups.Group 1 served as control. Mice in group 2 received water containing 200 ppm sodiumarsenite. Group 3 animals received caffeic acid (60 mg/kg body weight, i.p.)during arsenite treatment. Mice in group 4 only received caffeic acid. At theend of the experiment (21 days), tissue sampling was done and the levels ofsome oxidative-stress related biomarkers were measured in testicular tissue. Results:The results revealed significant decrease in testicular glutathioneperoxidase, superoxide dismutase and ferric reducing antioxidant power (FRAP) inarsenite‐treated animals relative to controls.Significant increment in testicular malondialdehyde was also detected inarsenite‐exposed group. Other measuredindices including reduced glutathione and protein carbonyls did not showsignificant alteration in arsenite‐treatedanimals relative to controls. Concurrentadministration of caffeic acid with arsenite notably alleviate alteredbiomarkers to the levels that were not significantly different from those incontrol group. Conclusion: Takentogether, caffeic acid notably restored testicular oxidative stress indices ofmice intoxicated with arsenite and it can be suggested as a promisingalleviative compound to mitigate testicular toxicity caused by arsenicexposure. The antioxidant and chelating properties may be proposed as theprinciple components important for the testicular securing influences ofcaffeic acid.

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