Background: While anabolic–androgenic drugs havesome therapeutic applications, their misemploy and self-administration inrelatively high dosages is widespread among athletic and non-athletic persons.Stanozolol (ST) is one of the most routinely misemployed anabolic–androgenicdrugs with the aim of enhancing physical performance. This work was aimed to evaluate the influences of ST on some circulating biochemical,hormonal and oxidative status indices alterations in endurance-trained rats. Methods: Male rats werehaphazardly designated to receive either placebo (group 1) or stanozolol (5mgkg-1 b.w.; group 2) for 8 weeks. All of the animals were engaged inendurance training protocol included running exercise on a rodent treadmill for30 minutes at a speed of 10 meters per minute, 5 successive days per week. Results: Glutathioneperoxidase and catalase activities in erythrocyte haemolysate were increasedsignificantly in group 2, but the increment of superoxide dismutase activity inST-treated group was not significant as compared to first group. Althoughvalues of all measured plasma enzymes increased in group 2, the increments werefound to be significant only for ALP and ALT. Plasma TSH concentration decreased significantly in ST-treated group. However,other quantified indices showed no significant alterations between groups. Conclusion: Itcan be concluded that stanozolol administration in endurance-trained rats caninduce some alterations in circulating markers of organ function and oxidativestatus which may be used for better understanding the side effects andpathophysiological aspects of nontherapeutic doses of anabolic–androgenicsteroids.

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