Chronic non-bacterial prostatitis (CNP) is themost common type of prostatitis and oxidative stress (OS)was shown to be highly elevated in prostatitis patients. Thisstudy aimed to investigate the protective effect of pen-toxifylline (PTX) on CNP induced by carrageenan in rats.Male adult Wistar rats (n=30) were divided into control,CNP and three treatment groups (n=6) includingCNP?cernilton and CNP?PTX groups. CNP wasinduced by single intraprostatic injection of 1% car-rageenan (100ll). Rats in treatment groups received orallycernilton 100 mg/kg and PTX at 50 and 100 mg/kg 1 weekafter CNP induction for 21 days. Prostatic index (PI),prostatic specific antigen (PSA), tumor-necrosis factoralpha (TNF-a), serum lipid peroxidation (MDA), bloodurea nitrogen, creatinine and histopathological changeswere compared between groups. There were significantincrease of PI, serum levels of PSA, TNF-aand MDA inCNP group at 29 day. In treatment groups, significanteduction in PI, serum levels of PSA, TNF-a, MDA andcreatinine was observed especially in rats treated with doseof 50 mg/kg of PTX. In CNP group, histopathologicalchanges of the prostate such as leucocyte infiltration, largeinvolutions and projection into the lumen and reducing thevolume of the lumen were observed as well. Whereas PTX,especially at dose of 50 mg/kg, could improve the above-mentioned changes remarkably in CNP treated rats. For thefirst time, our findings indicated that PTX improved CNPinduced by carrageenan in rats

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