Title : ( Electrophoretic extraction of highly monodispersed graphene quantum dots from widely polydispersed bulk and its cytotoxicity effect against cancer cells )
Authors: maryam davardoost , Hossein Ahmadzadeh , Elaheh Kafshdare Goharshadi , Azadeh Meshkini , elnaz sistanipour ,
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Abstract
In this work, we used a rapid (less than 10 s), inexpensive, and efficient method for exteraction of graphene quantum dots, GQDs, after thermal pyrolysis preparation from citric acid. The electrophoretic size fractionation was performed following the citric acid pyrolysis without using dialysis membrane. The last separated fraction was GQDs with a narrow size distribution and average size of ~60 nm. The characterization techniques showed that the GQDs exhibit strong photoluminescence properties which are highly desired for several applications in various fields such as cancer therapy. The cytotoxicity assesments demonstrated that the GQDs have higher toxicity (IC50 of 31.08 ± 2.71 μg/mL after 24 h) against human bone carcinoma cell line, Saos-2, compared to the bulk (IC50 of 65.06 ± 5.41 μg/mL after 24 h).
Keywords
, Graphene quantum dots Electrophoretic size fractionation Photoluminescence Cancer therapy Saos, 2 cell lines
@article{paperid:1080860,
author = {Davardoost, Maryam and Ahmadzadeh, Hossein and Kafshdare Goharshadi, Elaheh and Meshkini, Azadeh and Sistanipour, Elnaz},
title = {Electrophoretic extraction of highly monodispersed graphene quantum dots from widely polydispersed bulk and its cytotoxicity effect against cancer cells},
journal = {Microchemical Journal},
year = {2020},
volume = {159},
month = {December},
issn = {0026-265X},
pages = {105391--105399},
numpages = {8},
keywords = {Graphene quantum dots
Electrophoretic size fractionation
Photoluminescence
Cancer therapy
Saos-2 cell lines},
}
%0 Journal Article
%T Electrophoretic extraction of highly monodispersed graphene quantum dots from widely polydispersed bulk and its cytotoxicity effect against cancer cells
%A Davardoost, Maryam
%A Ahmadzadeh, Hossein
%A Kafshdare Goharshadi, Elaheh
%A Meshkini, Azadeh
%A Sistanipour, Elnaz
%J Microchemical Journal
%@ 0026-265X
%D 2020
