Biomaterials for Vasculogenesis and Angiogenesis, Year (2022-1)

Title : ( Calcium phosphate bioceramics for improved angiogenesis )

Authors: Farzad Kermani , Saeed Kargozar , Sergey V.Dorozhkin , Sahar Mollazadeh Beidokhti ,

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Calcium phosphate (CaP) bioceramics represent versatile biomaterials in the biomedical setting, especially for managing damaged hard tissues. Hydroxyapatite (HAp) and tricalcium phosphate (TCP) are among the most well-known CaPs bioceramics with diverse applications in tissue engineering. These substances offer exceptional characteristics for bone repair and regeneration, including excellent biocompatibility, osteoconductivity, osteoinductivity, and osteogenesis. The ability of CaPs to induce new blood vessel formation, that is, angiogenesis, is considered an additional advantage for their in vivo applications. The chemical composition and physical properties (e.g., topography) of CaPs bioceramics were identified as key determinants in advancing angiogenesis. Current research emphasizes making modifications in the basic formulation of CaPs for enhancing their angiogenic capacity. Doping of specific types of metallic elements (e.g., copper) into CaPs structure can create more potent angiogenic biomaterials. In addition, surface functionalization of CaPs bioceramics by proangiogenic growth factors and other chemicals was proven to be effective in improving neovascularization and accelerated wound healing. It is worth noting that CaPs can also be utilized for loading and delivery of proangiogenic cargoes (growth factors, phytochemicals, etc.) with the aim of accelerated tissue healing. Along with technological progress, the development of proangiogenic CaPs scaffolds by using three-dimensional (3D) printing provides great opportunities for researchers and scientists who work on tissue engineering and regenerative medicine. In this chapter, we have tried to present and criticize the angiogenic capacity of different types of CaPs bioceramics and draw a conclusion based on their usability for accelerating bone tissue healing based on the current knowledge. Previous chapter in book


Calcium phosphates Hydroxyapatite Tricalcium phosphate (TCP) Angiogenesis Neovascularization Bone tissue engineering
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author = {Kermani, Farzad and Saeed Kargozar and Sergey V.Dorozhkin and Mollazadeh Beidokhti, Sahar},
title = {Calcium phosphate bioceramics for improved angiogenesis},
journal = {Biomaterials for Vasculogenesis and Angiogenesis},
year = {2022},
month = {January},
issn = {2049-9485},
keywords = {Calcium phosphates Hydroxyapatite Tricalcium phosphate (TCP) Angiogenesis Neovascularization Bone tissue engineering},


%0 Journal Article
%T Calcium phosphate bioceramics for improved angiogenesis
%A Kermani, Farzad
%A Saeed Kargozar
%A Sergey V.Dorozhkin
%A Mollazadeh Beidokhti, Sahar
%J Biomaterials for Vasculogenesis and Angiogenesis
%@ 2049-9485
%D 2022