Background: Echinococcus granulosus is a parasitic tapeworm that causes echinococcosis or hydatid disease in humans and livestock. The larval stage of the parasite forms hydatid cysts in the liver, lungs, and other organs, which can cause serious health complications. This review aims to investigate previous literature related to tumors and Echinococcus granulosus. Methods: Nine databases (PubMed, Scopus, Google Scholar, Cochrane Library, Magiran, SID, Medline, Embase, and Lilacs) were searched for published articles on Echinococcus granulosus anti-tumor effects from January 2000 to January 2023. Fifteen affiliated articles with complete abstracts were included in this study. All data were extracted from interconnected papers and analyzed with R version 4.2.1 artificial intelligence software. Results: The anti-tumor effects of polymeric encapsulated antigens have been demonstrated in various types of cancer, including colon, lung, and breast cancer. One of the mechanisms by which polymeric-encapsulated antigens exert their anti-tumor effects is inducing apoptosis or programmed cell death in cancer cells. This leads to the death of cancer cells, which helps to slow or stop the growth of tumors.In addition to inducing apoptosis, polymeric-encapsulated antigens have also been shown to inhibit cell proliferation in cancer cells. The results showed that the encapsulated antigens could induce an immune response in mice and significantly reduce tumor growth. These findings suggest that polymeric encapsulated antigens from Echinococcus granulosus, including AgB and Ag5, have potential as an anti-tumor agent and warrant further investigation. Conclusion: Although the anti-tumor effects of polymeric encapsulated antigens are promising, further research is needed to understand its potential as a cancer treatment fully and to optimize its use in clinical settings. Overall, the findings suggest that polymeric encapsulated antigens may be a promising candidate for cancer treatment and warrant further investigation

Keywords