Background: It is well known that mastitis is a very common disease in dairy cows, and it is also responsible for a great deal of economic loss for dairy farms as a result of this disease. Bacteria, fungi, and algae are some of the organisms that are responsible for the cause of this disease. In most cases, antibiotics are the mainstay of treatment when it comes to mastitis. Nevertheless, dairy cows have developed resistance to antibiotics as a result of the long-term use of antibiotics. As a result, alternative methods are being explored to eliminate pathogenic microorganisms that cause mastitis, which is systematically reviewed in this study. Methods: Nine databases (PubMed, Scopus, Google Scholar, Cochrane Library, Magiran, SID, Medline, Embase, and Lilacs) were searched for published articles on the treatment of bacterial mastitis with Nanoformulations from January 2000 to August 2022. Fifteen affiliated articles with complete abstracts were included in this study. All data were extracted from interconnected papers and analyzed with R version 4.2.1 artificial intelligence software. Results: In spite of this, nanotechnology is a field that is growing rapidly, providing the possibility to manufacture new materials at the nanoscale level and with the potential to revolutionize the agriculture and food industries by offering novel treatment options for prevalent and costly illnesses like bovine mastitis. It has been shown in pilot studies that the combined formula of NP and antibiotics has demonstrated great success in treating mastitis. As a result of the intramammary infusion of nanosilver cream combined with ceftiofur, 93.33% of the cases have an effective therapeutic result. Conclusion: In view of the increasing ineffectiveness of current treatments for resistant bacteria, nanotechnology can be used to develop innovative products that address antimicrobial resistance as a major global issue.

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