Introduction: Healthcare-based Internet of Things (Healthcare-IoT) is a turning point in the development of health information systems. This emerging trend significantly contributes to enhancing users’ awareness of their health, ultimately leading to an extension in life expectancy. Security and privacy are among the greatest challenges for H-IoT systems. To establish complete safety and security in these systems, the implementation of mandatory security requirements is imperative. For this reason, this study identifies the necessary security requirements for H-IoT systems using a Meta-Synthesis approach. Methods: Initially, following the Seven-Stage Sandelowski & Barroso approach, the existing literature was searched in the Scopus and Web of Science databases. Among the 844 extracted articles from the period of 2010 to 2020, 78 final articles were reviewed and analyzed, leading to the identification of 51 security requirements. Subsequently, to assess the quality of the identified requirements and their overlap, interviews were conducted with two experts. Results: Finally, 14 security requirements, predominantly with technical and quantitative aspects, were identified for designing a Healthcare-IoT system and implementing security mechanisms. Conclusion: The findings of this study emphasize that addressing the identified 14 security requirements is crucial for safeguarding Healthcare-IoT systems and ensuring their robustness in the evolving health information landscape.

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