Interleukin-6 (IL-6) is excreting by adiposities, which increases by overweight and obesity. Obesity-related inflammatory marker is a risk factor for diseases. It has been reported that diet-induced weight loss lowers IL-6 levels. The effect of exercise training and other therapies on IL-6 is still unclear. We examined the effects of two weight loss protocols on plasma concentration of IL-6 in a sample of overweight and obese healthy sedentary female college students (N = 30; BF =29.53±3.1%, and BMI = 29.04±2.22 kg/m2), who were randomly assigned into three experimental and one control groups. Experimental Group I experienced twelveday researchers\' proposed diet (D); Experimental Group II experienced twelve-day researchers\' proposed diet along with twelve-day running training every other day mid consumption 250cc water beverage during per aerobic exercise period (AEDW), Experimental Group III experienced twelve-day researchers\' proposed diet along with twelve-day running training every other day and the consumption of 250cc 12% glucose beverage during each aerobic exercise (AEDG). The control group (C) remained sedentary with a normal diet. Total body weight in all three experimental groups was reduced (p<0.001). Also, IL-6 levels were significantly decreased, for both AEDW and AEDG groups (f = 22.962, p =0.022) in comparison with the control group, but significant decrease in resting levels of IL-6 in AEDW group was more than AEDG (p<0.001 vs. p<0.022). There was no significant change in the D and control group (f = 22.962, p= 0.781). After doing the exercise and enforcing diet protocols, AEDW and AEDG groups lost weight and showed a decrease in their resting IL-6 plasma concentration. These protocols are optional for decreasing resting plasma IL-6 levels and prevent prevalence disease as cardiovascular disease.

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