Title : ( Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15-lipoxygenase inhibitors )
Authors: Abdolhassan Doulah , Masoud Mirzaei Shahrabi , Mohsen Nikpour , Yaghoub Farbood ,
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Abstract
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5- e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
Keywords
, 1, (5, bromo, 2, chloro, 6, methylpyrimidin, 4, yl), 1, methylhydrazine; Dimethylthio carbamoylchloride; Pyrimidothiadiazine; Cyclocondensation.
@article{paperid:1023236,
author = {Abdolhassan Doulah and Mirzaei Shahrabi, Masoud and Mohsen Nikpour and Yaghoub Farbood},
title = {Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15-lipoxygenase inhibitors},
journal = {Journal of the Iranian Chemical Research},
year = {2011},
volume = {4},
number = {4},
month = {March},
issn = {2008-1030},
pages = {93--96},
numpages = {3},
keywords = {1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine; Dimethylthio
carbamoylchloride; Pyrimidothiadiazine; Cyclocondensation.},
}
%0 Journal Article
%T Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15-lipoxygenase inhibitors
%A Abdolhassan Doulah
%A Mirzaei Shahrabi, Masoud
%A Mohsen Nikpour
%A Yaghoub Farbood
%J Journal of the Iranian Chemical Research
%@ 2008-1030
%D 2011
