Title : ( Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken )
Authors: Shiba Yousefvand , Farshid Hamidi , M. Zendehdel , Abbas Parham ,
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Abstract
Abstract 1. The present study was conducted to investigate whether brain somatostatin increases feed intake in neonatal chickens. The mediating role of neuropeptide Y receptors on feed intake induced by somatostatin was investigated. 2. In this study, seven experiments were designed, each with four treatment groups (n=44 in each experiment). In Experiment 1, chicks received control solution and 0.5, 1, and 2 nmol of somatostatin through intracerebroventricular (ICV) injection. In experiments 2, 3 and 4, chickens were ICV injected with control solution and 1.25, 2.5 and 5 μg of B5063 (NPY1 receptor antagonist), SF22 (NPY2 receptor antagonist) and SML0891 (NPY5 receptor antagonist), respectively. In experiment 5, 6 and 7 chickens received ICV injection of B5063, SF22, SML0891, with a co-injection of +somatostatin, control solution and somatostatin. The cumulative feed intake was measured until 120 minutes post injection. 3. Somatostatin significantly increased feed intake in FD3 chicks. Both B5063 and SML0891 dose-dependently decreased feed intake compared with the control group, while SF22 led to a dose-dependent increase in feed intake. In addition, the hyperphagic effect of somatostatin significantly decreased with co-injection of B560 plus somatostatin (P<0.05), but SF22 and SML0891 had no effect on feed intake induced by somatostatin in chicks (P>0.05). 4. Based on the results of this study, it is likely that somatostatin increased feed intake and NPY1 receptor acts as a mediator in hyperphagic effect of somatostatin in neonatal chicks.
Keywords
Feed intake; ICV injection; neonatal chicks; NPY receptor’s antagonists; somatostatin
@article{paperid:1071289,
author = {Yousefvand, Shiba and Hamidi, Farshid and M. Zendehdel and Parham, Abbas},
title = {Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken},
journal = {British Poultry Science},
year = {2019},
volume = {60},
number = {1},
month = {January},
issn = {0007-1668},
pages = {71--78},
numpages = {7},
keywords = {Feed intake; ICV injection; neonatal chicks; NPY receptor’s antagonists; somatostatin},
}
%0 Journal Article
%T Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken
%A Yousefvand, Shiba
%A Hamidi, Farshid
%A M. Zendehdel
%A Parham, Abbas
%J British Poultry Science
%@ 0007-1668
%D 2019
