Iranian Journal of Veterinary Science and Technology, ( ISI ), Volume (11), No (1), Year (2019-7) , Pages (13-18)

Title : ( The Effect of resistance training and growth hormone injection on circulating IGF-1 and IGFBP-3 levels in a rat model )

Authors: Behnam Roozbeh , Mahtab Moazzami , Amir Rashidlamir , Zahra Moosavi , Ali Javadmanesh ,

Citation: BibTeX | EndNote

Abstract

Growth hormone has mitotic and anti-apoptotic effects which may increase proliferation and transformation of cells when it is expressed aberrantly. This study investigated the effects of resistance training and growth hormone injection on circulating IGF-1, IGFBP-3 levels and IGF-1/IGFBP-3 ratio in male Wistar rats. Thirty-two male Wistar rats were randomly assigned to a control group (C, n = 8), a resistance training group (RT, n = 8), a growth hormone injection group (GI, n = 8) and a resistance training + growth hormone injection group (RG, n = 8). The resistance training protocol comprised of climbing a ladder (5 days/week, 3 sets/5 reps) while carrying a weight suspended from the tail. The growth hormone (2 mg/kg/day, 5 days/week) was injected before an exercise session. Serum IGF-1, IGFBP-3 levels, and IGF-1/IGFBP-3 ratio were measured after 8 weeks. One-way ANOVA analysis was used for comparison of serum IGF-1 and IGFBP-3 levels between groups. Serum IGF-1 levels and IGF-1/IGFBP-3 ratio signifi cantly decreased, but serum IGFBP-3 levels showed no significant change in the RT group compared to the C group. Also, both serum IGF-1 and IGFBP-3 levels and IGF-1/IGFBP-3 ratio in GI and RG groups significantly increased compared to the other groups. In conclusion, resistance training decreases serum IGF-1 levels and/or IGF-1/IGFBP-3 ratio in normal condition. On the other hand, the growth hormone injection with and without the resistance training increases serum IGF-1 levels and IGF-1/IGFBP-3 ratio which could be noted as a condition with a higher risk of neoplasm.

Keywords

, Resistance training, Growth hormone injection, IGF-1, IGFBP-3, Cancer
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@article{paperid:1075422,
author = {Roozbeh, Behnam and Moazzami, Mahtab and Rashidlamir, Amir and Moosavi, Zahra and Javadmanesh, Ali},
title = {The Effect of resistance training and growth hormone injection on circulating IGF-1 and IGFBP-3 levels in a rat model},
journal = {Iranian Journal of Veterinary Science and Technology},
year = {2019},
volume = {11},
number = {1},
month = {July},
issn = {2008-465X},
pages = {13--18},
numpages = {5},
keywords = {Resistance training; Growth hormone injection; IGF-1; IGFBP-3; Cancer},
}

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%0 Journal Article
%T The Effect of resistance training and growth hormone injection on circulating IGF-1 and IGFBP-3 levels in a rat model
%A Roozbeh, Behnam
%A Moazzami, Mahtab
%A Rashidlamir, Amir
%A Moosavi, Zahra
%A Javadmanesh, Ali
%J Iranian Journal of Veterinary Science and Technology
%@ 2008-465X
%D 2019

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